- Research Interests
- Selected Publications
We are interested in understanding why we make particular actions. Our goal is to understand the neural bases of these decision-making processes and how they are influenced by sensory and motivation information. Currently, we are focusing on understanding the flow of information through cortical and basal ganglia circuits, and how pathologies that alter decision-making, like addiction, disrupt this process. We take an integrative approach using mice, where we can combine both simple and sophisticated quantitative behavioral measurements, with powerful molecular and genetic tools and monitoring techniques to delineate molecular mechanisms within specific cell-types in identified circuits that control decision-making processes.
- Gremel CM, Chancey JH, Atwood BK, Luo GL, Neve R, Deisseroth KM, Lovinger D, Costa RM (2015) Orbitofrontal CB1 receptor modulation of habit formation. In preparation.
- Gremel CM, & Costa RM (2015) Role of premotor cortex in decision-making strategies. Invited FrontiersCommentary in Frontiers in Neuroscience. In preparation.
- Barker JM, Corbit LH, Robinson DL, Gremel CM, Gonzales RA, Chandler LJ (2015) Corticostriatal circuitry andhabitual ethanol seeking. Invited review of Volterra Conference Proceeding, Alcohol.
- Gremel CM*, Cuzon Carlson V*, Lovinger D (2014) Prenatal ethanol exposure disrupts striatal circuitsunderlying habit formation. In revision, Nature Neuroscience.
- Holroyd KB, Adrover MF, Fuino RL, Bock R, Kaplan AR, Gremel CM, Rubinstein M, Alvarez VA (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. In press, Neuropsychopharmacology.
- Gremel CM, Costa RM (2014) Secondary motor cortex is necessary for goal-directed actions. Frontiers in Computational Neuroscience, 7(110): doi:10.3389/fncom.2013.00110
- Gremel CM & Costa RM (2013) Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nature Communications, 4:2264 doi: 10.1038/ncomms3264.
- Bock R, Shin JH, Dobi A, Markey E, Kramer PF, Funo R, Kaplan AR, Gremel CM, Christensen CH, Androver MF, Alvarez VA (2013) Synaptic potentiation at accumbal indirect-pathway neurons protects against cocaine addictive-like behaviors. Nature Neuroscience, 16(5): 632-638.
- Gremel CM, Young EM, Cunningham CL (2010) Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice. Behav Brain Res, 219(2): 358-362.
- Gremel CM & Cunningham CL (2010) Effects of disconnection of amygdala dopamine and nucleus accumbens Nmethyl-d-aspartate receptors on ethanol-seeking behavior in mice. Eur J Neurosci. 31(1):148-155.
- Gremel CM & Cunningham CL (2009) Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in expression of ethanol seeking behavior in mice. Neuropsychopharm. 34: 1443-1453.
- Gremel CM & Cunningham CL (2008) Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol conditioned behavior in mice. J. Neurosci, 28(5): 1076-1084.
- Cunningham CL, Gremel CM, Groblewski PA (2009) Genetic influences on conditioned taste aversion. In S. Reilly & T. R. Schachtman (Eds.), Conditioned taste aversion: Behavioral and neural processes (pp. 387-421). New York: Oxford University Press.
- Cunningham CL & Gremel CM (2006) Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. Pharm, Biochem, Behav, 85(3): 612-619.
- Gremel CM, & Cunningham CL (2007) Role of test activity in ethanol-induced disruption of place preference expression in mice. Psychopharm, 191(2): 195-202.
- Cunningham CL, Gremel CM, Groblewski PA (2006) Drug-induced conditioned place preference and aversion in mice. Nature Protocols, 1(4): 1662-1670.
- Gremel CM, Gabriel KA, Cunningham CL (2006) Topiramate does not affect the acquisition or expression of ethanol conditioned place preference by ethanol in mice. Alcohol Clin Exp Res, 30(5): 783-790.
- Bechtholt AJ, Gremel CM, Cunningham CL (2004) Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharm. Biochem. Behav, 79(4): 739 – 744.
Updated January 2015